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    Mechanism of Action :

              Pentosan is intended for the treatment of Interstitial Cystitis(IC). Pentosan Polysulfate Sodium is a semi-synthetically produced heparin-like molecular carbohydrate derivative which chemically and structurally resembles Glycosaminoglycans. It has a molecular weight of 400-600 Daltons.

               The mechanism of action of PPS in the treatment of Interstitial Cystitis are not yet established, however it is assumed that PPS is an anti-coagulant and helps in the repair of bladder tissues. The drug appears to adhere to the bladder wall mucosa where it may act as a buffer to protect the tissues from irritating substances in the urine.

           The Pharmacokinetics of PPS are as follows:

  • Absorption: ~3%
  • Metabolism: In the liver and spleen
  • Half-life: 4.8 hours
  • Elimination: In urine, 3% unchanged drug

The distribution of PPS is primarily to the uroepithelium of the genitourinary tract with lesser amounts found in the liver, spleen, lung, skin, periosteum and bone marrow. Erythrocyte penetration is found to be low in animals.

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References
  1. Panzera AK. Interstitial cystitis/Painful bladder syndrome. Urol Nurs. 2007;27(1):13-19.
  2. Carr LK, Corocs J, Njckel C, Teichman J. Diagnosis of Intersitial cystitis June 2007. Can Urol Assoc J. 2009;3(1):81-86.
  3. Van de Merve JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclaturefor painful bladder syndrome/interstitial cystitis: An ESSIC proposal. European Urology. 2008;53(1):60-67.
  4. Hanno PM. Interstitial cystitis - Epidemiology, Diagnostic criteria, Clinical Markers. Rev Urol. 2002;4(1):S3-S8.
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  8. Association of Reproductive Health Professionals. Screening, treatment, and management of IC/PBS. www arhp org. Accessed March 9, 2009.
  9. Evans RJ. Pathophysiology and clinical presentation of interstitial cystitis. Avd Stud Pharm. 2005;8-14.
  10. National Kidney and Urologic diseases Information Clearinghouse(NKUDIC). Interstitial cystitis/ painful bladder syndrome. www kidney niddk nih gov. Accessed March 9, 2009.