Pentosan is intended for the treatment of Interstitial Cystitis(IC). Pentosan
Polysulfate Sodium is a semi-synthetically produced heparin-like molecular
carbohydrate derivative which chemically and structurally resembles
Glycosaminoglycans. It has a molecular weight of 400-600 Daltons.
The mechanism of action of PPS in the treatment of Interstitial Cystitis are not
yet established, however it is assumed that PPS is an anti-coagulant and helps
in the repair of bladder tissues. The drug appears to adhere to the bladder wall
mucosa where it may act as a buffer to protect the tissues from irritating
substances in the urine.
The Pharmacokinetics of PPS are as follows:
Metabolism: In the liver and spleen
Half-life: 4.8 hours
Elimination: In urine, 3% unchanged drug
The distribution of PPS is primarily to the uroepithelium of the genitourinary
tract with lesser amounts found in the liver, spleen, lung, skin, periosteum and
bone marrow. Erythrocyte penetration is found to be low in animals.