Comfora (PPS) is effective in improving the symptoms of patients suffering from
IC and provides relief from pain and discomfort. This is the only FDA-approved drug
taken orally for bladder pain and discomfort. The usual dosage is 100-mg capsules
thrice daily.
How Does Comfora Help in IC?
The exact mechanism of function of Comfora is not clearly understood. There are
several proposed theories by which Comfora is thought to function. It is believed
that the drug could repair and heal the damaged parts of the GAG layer in the bladder
(Figure 4).
Comfora does not cure IC completely; however, it may help in relief of symptoms
such as bladder pain, discomfort and urgency in urination.
How Long should I Take Comfora?
Several studies have shown that a minimum duration of 3 to 6 months is necessary
to provide moderate symptom relief. Therefore, doctors must encourage the patients
to continue the medications for adequate period of time.
Safety
The safety of the drug in children and adolescents below the age of 18 years has
not yet been established.
Very mild adverse events were noted, such as nausea, loss of hair, rashes, headaches
and loose motion. Comfora must be administered with caution in patients with bleeding
disorders, liver and spleen insufficiencies. Hence, it is very important to inform
your doctor about all the previous ailments, and previous and current medications.1,2
