Comfora

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Why should Comfora be prescribed for Interstitial Cystitis?

comfora prescription

             Comfora (Pentosan PolysufateSodium) is effective in improving the symptoms of patients suffering from IC and provides relief from pain and discomfort. This is the only FDA-approved drug taken orally for bladder pain and discomfort. The usual dosage is 100-mg capsules thrice daily.

             The exact mechanism of function of Comfora is not clearly understood. There are several proposed theories by which Comfora is thought to function. It is believed that the drug could repair and heal the damaged parts of the GAG layer in the bladder.

             Several studies have shown that a minimum duration of 6 months to 1 year is necessary to provide moderate symptom relief. Therefore, doctors must encourage the patients to continue the medications for adequate period of time.

            The safety of the drug in children and adolescents below the age of 18 years has not yet been established.Very mild adverse events were noted, such as nausea, loss of hair, rashes, headaches and loose motion. Comfora must be administered with caution in patients with bleeding disorders, liver and spleen insufficiencies. Hence, it is very important to inform your doctor about all the previous ailments, and previous and current medications.

References
  1. Panzera AK. Interstitial cystitis/Painful bladder syndrome. Urol Nurs. 2007;27(1):13-19.
  2. Carr LK, Corocs J, Njckel C, Teichman J. Diagnosis of Intersitial cystitis June 2007. Can Urol Assoc J. 2009;3(1):81-86.
  3. Van de Merve JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclaturefor painful bladder syndrome/interstitial cystitis: An ESSIC proposal. European Urology. 2008;53(1):60-67.
  4. Hanno PM. Interstitial cystitis - Epidemiology, Diagnostic criteria, Clinical Markers. Rev Urol. 2002;4(1):S3-S8.
  5. Heck BN. Interstitial cystitis:Enhancing early identification in primary care settings. JNP. 2007;3(8):509-519.
  6. Mattox TF. Interstitial cystitis in adolscents and children:a review. J Pediatr Adolesc Gynecol. 2004;17:7-11.
  7. Teichman JMH, Parsons CL. Contemporary clincal presentation of interstitial cystitis. Urology. 2007;69(4A):41-47.
  8. Association of Reproductive Health Professionals. Screening, treatment, and management of IC/PBS. www arhp org. Accessed March 9, 2009.
  9. Evans RJ. Pathophysiology and clinical presentation of interstitial cystitis. Avd Stud Pharm. 2005;8-14.
  10. National Kidney and Urologic diseases Information Clearinghouse(NKUDIC). Interstitial cystitis/ painful bladder syndrome. www kidney niddk nih gov. Accessed March 9, 2009.